The following are 35 orthopedic and spine device companies that need attention next year.

4Web Medical (Frisco, Texas). 4Web Medical uses 3D printing technology to manufacture orthopedic and spinal implants. The company was founded in 2008 and has now grown to include five FDA-approved implant systems. In October, 4Web launched an independent anterior lumbar spine system. The first operation was performed by James Lynch, MD, CEO of SpineNevada in Reno.

Aesculap Planting System (Central Valley, Pennsylvania). Aesculap provides a set of hip and knee implants, navigation and spine technology, including ActivL artificial discs. The company's knee joint product portfolio provides advanced surface technology to prevent implant wear and release of metal ions.

Atec (Carlsbad, California). Atec focuses on developing new methods of spinal surgery. In February, the company opened a new headquarters in Carlsbad, California to add educational space, biomechanics laboratories, and processing centers. The company has approximately 300 employees and is expected to continue to build teams this year.

Arthrex (Naples, Florida). Arthrex is a global orthopedic device company specializing in arthroscopy. It develops more than 1,000 products and programs every year. In December, Arthrex launched the SwiveLock ACL repair kit to treat primary ACL tears.

Bioventus (Durham, North Carolina). Bioventus is a global company specializing in minimally invasive joint therapy and surgical biologics. The company's orthopedic biological products promote bone formation, including allografts and synthetic products. The company launched its initial public offering in February.

Camber Spine (Prussia, Pennsylvania). Camber Spine developed minimally invasive techniques designed by surgeons to treat complex spinal diseases. The company has 20 FDA-approved spinal products and more than 28 valid or issued patents. Founded in 2010, Camber Spine incorporates 3D printing into its implants.

ChoiceSpine (Knoxville, Tennessee). ChoiceSpine is a private spinal implant company established in 2006. It has a series of regenerative and bone biology products, including lateral fusion systems and implants manufactured using 3D printing technology. The company uses impregnated hydroxyapatite for its internal products.

Conformis (Billica, Massachusetts). Conformis uses advanced 3D imaging technology to develop patient-specific knee implants. The company's proprietary iFit Image-to-Implant platform sells joint implants, the size and shape of which are individually adjusted according to the patient's anatomy for partial and total knee replacement.

Conventus Orthopedics (Maple Grove, Minnesota). Conventus focuses on 3D fracture fixation technology. In 2020, Conventus acquired Flower Orthopedics, which provides disposable orthopedic surgery products in sterile packaging. Since then, it has hired two executives to lead sales and R&D.

DePuy Synthes (West Chester, Pennsylvania). DePuy Synthes is part of Johnson & Johnson Medical Devices Corporation. It provides joint reconstruction, trauma, spine and sports medicine products. The DePuy Synthes Attune knee system has been implanted in more than 1 million patients worldwide.

DJO (Lewisville, Texas). DJO is an orthopedic products company with more than 5,000 employees and 1,000 medical devices. It was acquired by Colfax Corp., a diversified technology company in 2019, and continues to produce orthopedic braces, surgical products and spinal technology.

Exactech (Gainesville, Florida). Exactech develops orthopedic implants, devices and technologies. In February, the company launched the next-generation Exactech GPS-guided personalized surgery system for knee and shoulder replacements.

Globus Medical (Audubon, Pennsylvania). Globus Medical is a manufacturer of spinal equipment and technology. The company has spinal implants, robots and navigation platforms for complex and minimally invasive surgery. ExcelsiusGPS, Globus' spine robotic technology, assists surgeons in placing pedicle screws and provides navigation for transforaminal and lateral lumbar interbody fusion.

GS Medical (Mission Viejo, California). GS Medical is a global medical device company focusing on spinal disease care, providing a variety of solutions from implants to disposables. GS Medical is committed to providing the most advanced and innovative spine products to provide better patient care, working closely with surgeons, distributors and hospital partners to create customized solutions that meet their needs.

Integra LifeSciences (Princeton, New Jersey). Integra LifeSciences is a global medical device company that provides orthopedics, neurosurgery, and general and reconstructive surgery products. It was established in 1989 and has now grown to have 3,000 employees. In January of this year, the company acquired ACell, a regenerative medicine company.

Life Spine (Huntley, Illinois). Life Spine was established in 2004 and has grown to 70 employees worldwide. The company provides biologics, ankle and limb fixation devices, and spinal fusion products. More than 1,000 surgeons from 48 states and 32 countries use Life Spine products.

LimaCorporate (San Daniel del Friuli, Italy). LimaCorporate is a global orthopedic company specializing in joint replacement surgery. It includes shoulder, elbow, hip and knee products. In 2019, LimaCorporate cooperated with the New York City Special Surgery Hospital to establish an additive manufacturing 3D printing facility for custom implants in the hospital.

Medacta (Franklin, Tennessee). Medacta provides minimally invasive orthopedic surgery products and is known for its minimally invasive anterior hip replacement technology. The company's MySolutions technology provides personalized preoperative planning, and develops personalized motion models and 3D planning tools for hip, knee, shoulder, and spine surgery.

Medtronic (Dublin, Ireland). Medtronic is a medical technology company that provides spine and pain management products. The company's Mazor X Stealth Edition is a robotic technology designed to help surgeons perform more precise spinal surgery. The technology also allows real-time visualization of the patient's anatomy.

MicroPort Orthopedics (Palo Alto, California). MicroPort developed hip and knee implants and distributed them to surgeons in 70 countries. In August last year, the company cooperated with the virtual reality surgery training platform Osso VR to provide surgeons with training on total hip and knee replacement equipment, which has been used in 600,000 cases worldwide.

Mizuho OSI (Union City, California). Mizuho OSI develops operating tables and positioning devices for orthopedic and spine cases. The technology designed by the company can reduce the fatigue of doctors and improve the safety of patients during surgery. In September, the company acquired the Air Barrier System, an infection control device used in spinal and hip surgery.

Nanovis (Carmel, Indiana). Nanovis develops an orthopedics and infection control technology platform for patients undergoing spinal surgery. The company has a series of spinal implants with antiseptic capabilities to prevent local infections. Last year, Nanovis reported a record sales month in June and received the FDA's first nanotechnology license for pedicle screws in April.

Nexxt Spine (Noblesville, Indiana). Nexxt Spine designs and manufactures all spinal implants and 95% of the instruments. In December last year, the company launched a cervical system including 3D laser printed titanium implants.

NuVasive (San Diego). NuVasive focuses on spine techniques for minimally invasive surgery. The company has a single scalable platform Pulse, which integrates multiple technologies to improve the repeatability of workflow and results. These technologies include neuromonitoring, radiation reduction, imaging, and navigation.

Nvision Biomedical Technologies (San Antonio). Nvision is a medical device and biologics company specializing in spine and limb products. In October, the company's osteotomy wedge system made using Invibio's PEEK-OPTIMA HA Enhanced (a fusion enhancement material) received the first FDA approval.

Orthalign (Aliso Viejo, California). Orthalign is a private medical device company specializing in orthopedic surgery. Its technology has been used in more than 150,000 programs. In November, Dr. Michael Ast, a surgeon at the Special Surgery Hospital in New York City, performed the first operation using his next-generation handheld navigation technology.

Orthofix (Lewisville, Texas). Orthofix was established in 1980 as an orthopedic equipment company and has grown to have 1,000 employees. It distributes spine and limb products to surgeons in more than 70 countries. Last March, the company acquired Fitbone limb extension technology.

OrthoPediatrics (Warsaw, Indiana). OrthoPediatrics was established in 2006 and is dedicated to the development of orthopedic implants for children. The company has 35 surgical systems in the subspecialty of trauma and deformity, scoliosis and sports medicine. It distributes products in 44 countries.

SeaSpine Orthopedics (Carlsbad, California). SeaSpine has a series of orthopedic biology products for spine, hip and limb surgery. It also develops implants for minimally invasive spinal surgery, including the Regatta side plate system launched in January. SeaSpine sells products in more than 30 countries.

SI-Bone (Santa Clara, California). SI-Bone has developed iFuse implants for minimally invasive sacroiliac joint fusion. More than 2,000 surgeons have been trained in this procedure, which has been performed more than 45,000 times. Last year, Aetna, Humana, and multiple regional payers updated their insurance policies to include the iFuse program.

Smith + nephew (London). Smith+Nephew is a medical device company with a rich portfolio of orthopedic products. The company focuses on hip and knee surgery, sports medicine and wound management. In January, Smith+Nephew acquired the limbs business of Integra LifeSciences for USD 240 million.

Stryker (Kalamazoo, Michigan). Stryker is an orthopedic device company with more than 40,000 employees. The company owns 8,883 patents worldwide and spent $971 million on research and development in 2019. It provides joint replacement, lower extremity, spine and sports medicine products. In November, Stryker completed the acquisition of Wright Medical, a lower extremity equipment company, for approximately US$5.4 billion.

WishBone Medical (Warsaw, Indiana). WishBone is an orthopedic equipment company focusing on products for pediatric patients. It provides surgeons with pediatric instruments and implants in sterile packaging disposable surgical kits. In October, it received US$20 million in financing from private equity firm LKCM Headwater Investment.

Zavation (Flowood, Miss.). Zavation is an employee-owned company focused on spine products. It has a portfolio of spinal systems, implants and biologics. In February, the company launched Labyrinth, a porous PEEK interbody fusion cage.

Zimmer Biomet (Warsaw, Indiana). Zimmer Biomet is a musculoskeletal products company with equipment sold in more than 100 countries. It has instrument systems and implants suitable for knee joints, hip joints, spine, sports medicine and dental surgery. In February, the company announced plans to spin off its spine and dental businesses into a separate company

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